Here's another post showing spreads from my other Moleskine. To be honest I kinda prefer having the lines go across...it makes it easier when I'm writing notes down and it gives me something to measure with when I'm drawing.
I draw in the Moleskines with ballpoint pen, which often give a really scratchy, crude look, but sometimes I think that can work to an advantage if you do it right. All the blotches of ink and light line-work can give the sketch a different kind of feel. Drawing with ballpoint pen feels different because the pen glides across the page more easily, and sometimes is the reason why I prefer drawing in ballpoint pen over pencil (sometimes).